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Additionally, the cytoprotective characteristics of activated protein C, such as anti-inflammatory, anti-apoptotic, and endothelial barrier stabilization, seen in endotoxemia and sepsis mouse models, have also been reported to have neuroprotective effects in IS models [112]

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400 These findings suggest that minihepcidins could be used alone to prevent iron overload disease or as an adjunct therapy with iron chelating agents

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