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The administration of IPRA significantly decreased hepatic lipid concentrations and plasma levels of ALT/AST in a dose-dependent fashion

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Tissue-reactive and carcinogenic metabolites formed as a result of phase I reaction are rendered harmless by conjugation with moieties such as glutathione

Prevention strategies include maintaining adequate calories (minimum 1,200/1,500), prioritizing protein (80-100g daily), and taking biotin supplements (2,500-5,000mcg daily)

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