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Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig

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ER was also increased by treatment with E2 (both in the absence and presence of LPS), indicating effective estrogen treatment response in macrophages

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Observational studies can show a link, but they cannot prove that the medication directly caused the result