does tirzepatide cause birth defects Use of GLP-1 drugs early in pregnancy should not alarm, analysis suggests How GLP-1 weight-loss drugs can

More serious but rare side effects can include pancreatitis, changes in heart rate, and potential thyroid tumors

Loose skin after weight loss is due to carrying extra weight for an extended amount of time

Jumping back to a high dose after a long gap dramatically increases the risk of severe [nausea, vomiting, and diarrhea](/guides/semaglutide-nausea-how-to-manage-common-side-effect)

Injecting two doses close together to "catch up" is not safe

Horiuchi Y, Wettersten N, Asami M, Yahagi K, Komiyama K, Yuzawa H, Tanaka J, Aoki J, Tanabe K (2025) Glucagon-like peptide-1 receptor agonists improve outcomes in individuals with type 2 diabetes with and without heart failure

Herczeg-Lisztes, W