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Importantly, GLP-1 analogs appear to exert their anti-obesity effects through central pathways that do not involve MC4R, as well as via peripheral mechanisms involving the vagus nerve [48, 49]

And then you couldn't quite finish it, because it was a little sickly sweet, a bit too chalky, or it left you feeling more bloated than before

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GLP-1 and GIP are incretin hormones known for stimulating insulin secretion in a glucose-dependent manner, slowing gastric emptying, and reducing appetite

10.1073/pnas.1219451110 13 FerreP.PhanF.FoufelleF

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