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Semaglutide at higher doses (2.4 mg weekly) has shown the most robust evidence for NASH resolution in clinical trials, achieving resolution in 59% of patients

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While multi-agonism with incretin hormones and glucagon has demonstrated great therapeutic potential, the conceptual approach of polypharmacology has also been extended to other hormone combinations

On the other hand, perfusion of isolated hearts with 25-dideoxyadenosine (Ddox) to inhibit transmembrane AC (tmAC) did not affect the cardioprotective actions of GLP-1(2836), but did reduce the cardioprotective effect of GLP-1 (67.6 5.8 mmHg, n = 3, vs