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A major limitation is that current evidence for direct molecular crosstalk between ferroptosis and cuproptosis derives from studies in different cancer types or cell line models

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Overall, across the two repeat experiments for Cagri and CagriBB bound to the CTR, the conformational equilibrium between the bypass vs CT-like state was similar, suggesting that the salt bridge/ionic lock is sufficient to preferentially stabilize the bypass conformation at CTR (Supplementary Fig