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Additionally, the GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) dual agonist tirzepatide can induce weight loss of 10%20%, and the results of the ongoing SURPASS-CVOT trial may provide more clarity on whether weight loss itself is an independent driver of CV protection (74)

Applications: Used for treating infertility in women by inducing ovulation and addressing hypogonadism in men

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Involvement of FoxO1 in the effects of follicle-stimulating hormone on Inhibition of apoptosis in mouse granulosa cells

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