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J Med Chem
Tirzepatide, also known as Zepbound, is a medication that is approved by the FDA for weight loss in people who are obese (with a body mass index (BMI) over 30 kg/m2) or overweight (BMI over 27 kg/m2) with medical conditions such as diabetes or heart disease
Hypoglycemia risk remains low with this combination when used without insulin or sulfonylureas, as both medications have glucose-dependent mechanisms
On tirzepatide, it most commonly manifests as a dull, diffuse soreness in the legs, arms, or trunk
In addition, T2D prohibits neuronal autophagy, which involves the elimination of A, leading to the accumulation of A and other misfolded proteins with subsequent exaggeration of AD neuropathology (Lai et al
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