Acknowledgments We thank Bojana Mircetic for language editing
The studied figure of ~1,485 mcg for a 70 kg adult was a slow intravenous injection given in a sleep laboratory under polygraphic monitoring it has never been administered subcutaneously to a human in any published study, and rendering it as a number of units on an insulin syringe would convert a monitored hospital procedure into an at-home target it was never validated as
In addition, cellular cysteine is also available through the transsulfuration (TSS) pathway from the sulfur-containing amino acid methionine
doi: 10.1016/S2213-2600(21)00511-7 2 MarkLLLeonardBBEricBLouis-PhilippeBChrisBRolandBet al
RECOMMENDATIONS The rising prevalence and associated complications of EOT2D is a prominent global issue
Administer the concomitant oral medication at least 1 hour prior to SYMLIN injection or 2 hours after SYMLIN injection if the rapid onset or threshold concentration of the concomitant medication is a critical determinant of its effectiveness (such as with analgesics, antibiotics, and oral contraceptives) [see Drug Interactions (7.2) and Clinical Pharmacology (12.3)]