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This triple mechanism distinguishes it from existing approved agents semaglutide, for example, acts on the GLP-1 receptor only, whilst tirzepatide is a dual GIP/GLP-1 receptor agonist and is being investigated to determine whether broader receptor engagement offers additional metabolic benefit

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Vitamin B12 is a water-soluble vitamin, also called cobalamin

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Head-to-head comparisons indicate that tirzepatide outperforms dulaglutide, semaglutide, insulin degludec, and glargine in both glucose lowering and weight reduction

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Serious side effects are rare with properly dosed semaglutide from licensed 503A compounding pharmacies

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