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Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type 2 diabetes

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For SGLT2 inhibitor users, the cumulative incidence of treatment discontinuation was 27.9% (95% CI 27.6, 28.1) at 1 year and 45.9% (95% CI 45.5, 46.2) at 3 years, when using a grace period of 90 days