GLP-1s help to reduce the impacts of chronic stress and help to alter food reward pathways in positive ways and may help reduce alcohol and other substance use disorders (Mozafarriun et al 2025)
The HSS Lifestyle Medicine team is also interested in studying how GLP-1 agonists might interact with other treatments that promote behavioral change
Yang et al
Compouned Semaglutide works by mimicking a hormone naturally produced in your intestines known as GLP-1, according to the FDA
Keep in mind that an 800-calorie deficit is significant and not typically recommended to promote safe, sustainable weight loss
Even with proper supplementation and a nutrient-rich diet, some GLP-1 patients still reduce their overall food intake enough to create gaps in key nutrients, such as vitamin D, B12, and protein, that are critical for maintaining skin elasticity, hydration, and overall resilience