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doi: 10.3389/fped.2025.1514722 Received 21 October 2024 Accepted 03 January 2025 Published 27 January 2025 Volume 13 - 2025 Edited by Sachith Mettananda, University of Kelaniya, Sri Lanka Reviewed by Nishant Chakravorty, Indian Institute of Technology Kharagpur, India J.W

Serum markers of mitochondrial damage and death, including glutamate dehydrogenase (GDH), nuclear DNA (nDNA) and mtDNA have been investigated as clinically useful surrogate markers capable of indicating mitochondrial lysis following hepatocyte necrosis in APAP hepatotoxicity

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14 A history of panic disorder (negative likelihood ratio [LR] = 0.26) or palpitations lasting less than five minutes (LR = 0.38) make a cardiac etiology less likely