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[16] [17] This sustained weight reduction while on treatment may provide ongoing joint protection and symptom relief

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Heavier individuals often see faster initial losses due to higher caloric deficit

These inherent constraints preclude causal inference between GLP-1 RAs and NAEs while preventing incidence rate calculations 75

Appetite Suppression and Glycemic Control It slows gastric emptying, reduces hunger, and enhances insulin release, leading to improved blood glucose control and weight reduction