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Always follow the manufacturer's recommended titration schedule in the SmPC, and consider extending the time at lower doses if patients experience significant gastrointestinal symptoms

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An intention to treat analysis (without neoadjuvant therapy), results of resection are potentially better than transplantation with higher drop-off in de novo patients post-neo-adjuvant chemotherapy

External references for further reading All reference valid and accessible on July 2026 Nauck MA, Meier JJ