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As a result, there is an overexpression of p16 and p21 [90]

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Moreover, MN rats exhibited colonic structural injury, an increased Firmicutes-to-Bacteroidetes ratio, an elevated relative abundance of Allobaculum and Desulfovibrio , greater production of uremic toxin precursors, and reduced levels of SCFAs [136]

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Scientific Reports , 14 (1), 5002

Briefly, significant but variable HbA1c reductions were observed across multiple GLP-1 RA dosages either as monotherapy or in combination with other OADs