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This evolutionary conservation strongly indicates that the biological functions of this peptide are fundamental to mammalian survival

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Build up concentration gradually over weeks rather than starting at maximum strength

Explore novel modalities such as PROTACs (targeting ACSL4 and Nrf2), gene therapies (e.g., AAV-mediated SLC7A11 overexpression in PT cells), and epigenetic modulators (e.g., m 6 A inhibitors that regulate ferroptosis-related gene expression)

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