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The gross-to-net bubble keeps inflating: Rebates cut list prices roughly in half Patients cover ~22% of net costs Insurers capture ~90% of rebate value Despite higher list prices, the actual net cost per GLP-1 prescription has stayed flat

DPP-4 inhibitors increase glycemic control in patients with type 2 diabetes through multiple mechanisms

However, it is important to distinguish between evidence-based medical treatments like tirzepatide and dietary supplements, which are not regulated as pharmaceuticals and lack the same level of clinical validation

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doi: 10.1186/s12879-018-2991-2

This is equivalent to about two 8-ounce cups of brewed coffee