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The guide details experimental parameters for testing collagen production (1-100 M concentrations, 24-72 hour protocols), MMP activity measurement, and angiogenesis readouts

doi:10.3389/fendo.2021.721135

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Among the patients who develop NASH, 1020% will progress to higher-grade fibrosis and approximately 5% will develop overt cirrhosis (1) ( Figure 1 Triglycerides (TG) accumulation is likely one of the first steps in the pathophysiology of NAFLD as a result of an impaired free fatty acid (FFA) metabolism in the liver (Figure 2)

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