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Studies have found that GLP-1R is widely distributed on pancreatic and other tissues and has multiple biological effects, such as reducing neuroinflammation, promoting nerve growth, improving heart function, suppressing appetite, delaying gastric emptying, regulating blood lipid metabolism, and reducing fat deposition

Nat Rev Dis Primers 2:16008 Khan SR, Finlayson B, Hackett RL (1979) Scanning electron microscopy of calcium oxalate crystal formation in experimental nephrolithiasis

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The slowing of brain activity from increased chloride movement causes the body to calm down, become drowsy, and eventually end up in an unconscious state that is needed for surgery