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However, ondansetron is a 5-HT3 receptor antagonist that works in the chemoreceptor trigger zone of the brain, whereas semaglutide acts primarily on GLP-1 pathways in the gut and central nervous system, so combining them addresses nausea through different mechanisms

Sex differences, influenced by hormonal fluctuations and neural circuit variability, predispose women to heightened pain perception

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Firstline therapy for fit patients eligible for diseasedirected therapy is Dara+CyBorD (daratumumab, cyclophosphamide, bortezomib, and dexamethasone) as initial induction therapy [22, 79]