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Significant detoxification has occurred Reply 48 people found this helpful

Understanding why refrigeration is necessary comes down to basic chemistry: proteins denature at higher temperatures

BMJ 2020;369:m1361.ArticlePubMedPMC 1038

The FDA noted that this delay in enforcement will allow patients a reasonable amount of time to transfer their prescriptions to different pharmacies to obtain the FDA-approved drug as well as to allow local pharmacies to adjust their stocking and ordering patterns to account for shifts in patient demand

Dose escalation is the standard clinical approach, yet many patients reach a ceiling dose or experience side effects that limit further increases

Instead, patients begin at a low starting dose and gradually increase over 1620 weeks in a process called titration