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Studies have characterised MC1R-mediated anti-inflammatory signalling in macrophage and neutrophil models , examining cAMP-mediated NF-B suppression and cytokine production inhibition and and have examined MT-1s effects in inflammatory bowel disease, arthritis, and ischaemia-reperfusion injury models where melanocortin anti-inflammatory biology has been characterised

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Tang X, Wu H, Mao X, Li X, Wang Y (2020) The GLP-1 receptor herbal agonist morroniside attenuates neuropathic pain via spinal microglial expression of IL-10 and beta-endorphin

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