Key symptoms include: Fatigue: A pervasive sense of tiredness that does not improve with rest
Our team is currently validating this hypothesis using knockout cell lines specifically deficient for GSH synthesis
Resultant oxidative DNA base lesions have the potential to mutate some genetic material, which would impair the integrity of the genome by preventing transcription and replication and by generating mutagenesis (116)
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Int J Mol Sci 18:1544 Sahoo SS, Ramanand SG, Gao Y, Abbas A, Kumar A, Cuevas IC et al (2022) FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity
In the absence of sufficient glutathione buffering, oxidative damage accumulates in pancreatic -cells, hepatocytes, adipocytes, and vascular tissues