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While PDE5 inhibitors are effective for many patients, some men experience inadequate response or persistent low libido, prompting increased clinical interest in centrally acting therapies such as PT-141

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Moreover, more recently a family of proteins called peroxiredoxins has been recognized as catalyzing the reduction of H 2 O 2 by GSH and/or other thiols, but with cysteine in its thiolate form, in their active sites rather than selenium-cysteine (Strange et al., 2000)

They represent a lasting shift in cardiometabolic care, with actuarial implications that will unfold over years

Expanded access may improve population-level diabetes outcomes while reducing disparities in care

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