They lower blood glucose levels, slow gastric emptying, lower serum cholesterol and triglyceride levels, reduce liver fat content, decrease the highly inflammatory visceral fat, enhance microvascular (!) blood flows in the muscle tissue, reduce muscle-produced inflammation, microglial activation (neuroinflammation), and enhance neuroplasticity
It applies the standard MHRA thresholds, then applies the NICE NG246 ethnic adjustment (27.5, or 24.5 with a condition) for the relevant ethnic backgrounds
Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group
In recent years, GLP-1 approvals have expanded beyond blood sugar management and weight loss to include other organs, like the heart, kidneys, and liver
A single-arm trial showed that liraglutide reduced, from pre-exposure to 12 weeks post-exposure, the occurrences of uncontrolled and emotional eating in 36 women with obesity and PCOS 216
Available from: 162.Kripalani S., Jackson A.T., Schnipper J.L., Coleman E.A
