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6) Pro-Regenerative Crosstalk Human-centric reviews 9 detail how IGF-1 interacts with cytokines (e.g., IL-6) and niche signals to regulate repair dynamics, offering a systems-level explanation for why restoring IGF-1 signaling aligns with better recovery trajectories

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Antioxidants can limit the production of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor (TNF-) (36)