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Reduced kidney function and folate status are major confounders, since both can raise MMA and/or homocysteine independently of B12

Given the title of the paper by Foyer and Halliwell (1976), it is intriguing that notable exceptions to this redundancy are glutathione synthesis, ascorbate synthesis, and chloroplastic GR activity (Cairns et al

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If side effects persist beyond a few days or cause significant distress, patients should consult their GP to discuss alternative formulations or dosing schedules