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One of the most widely studied mechanisms of action for toxic metals is oxidative damage due to direct generation of free radical species and depletion of antioxidant reserves

The first few weeks, and every dose step-up, are usually the more difficult periods

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In the more accessible organs (the oesophagus and anorectum), manometry provides direct measures of intraluminal pressure 22,23

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HIF-2 can be used to mediate SOX9 in OA to affect cartilage matrix synthesis, and induce the expression of some catabolic factors (including some matrix metalloproteinases, inflammatory factors, etc.) to affect the destruction and degradation of articular cartilage (88)