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The colon lining needs both a tight barrier and good micro-blood flow to heal

In a phase 1 trial, a PYY analogue (Y14 peptide) administered subcutaneously at 7- to 14-days intervals was safe and potentially efficacious (WL between 2.9 and 3.6 kg at 31 days, with a 3855% reduction in food intake vs

Chin J Physiol 42:171179 Johns RA, Moscicki JC, DiFazio CA et al (1992) Nitric oxide synthase inhibitor dose-dependently and reversibly reduces the threshold for halothane anesthesia

This is where peptides like KPV become relevant, because they target NF-kB directly