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A myriad of new oral, topical, and combination therapies for melasma have been introduced to expand our repertoire of therapies, and warrant additional trials to substantiate their efficacy and safety

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[117] Pigment Epithelium-Derived Factor (PEDF) may have neuroprotective and anti-angiogenic properties in DR and AMD [118] , Fibroblast Growth Factor (FGF) and basic FGF (bFGF) may stimulate corneal healing and repair [118] [119] , Insulin-Like Growth Factor-1 (IGF-1) may promote retinal neuroprotection [120] , Platelet-Derived Growth Factor (PDGF) effectively prevents photoreceptor degeneration by inhibiting apoptosis, offering a promising therapeutic approach to mitigate photoreceptor loss without the adverse effects of inducing retinal angiogenesis

Identity is better supported by a separate method such as mass spectrometry or NMR

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That mechanism is why clinicians reach for it first for age-related GH decline: energy, sleep quality, recovery, and body composition are the common goals