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Blood Clot: Since smoking greatly diminishes blood circulation there is a greater chance of clots forming those clots can severely jeopardize your limbs and extremities and lead to amputations

In light of this, the riskbenefit assessment in smokers suggests the use of a lower starting dose than in non-smokers (25 mg instead of 50 mg), with a further dose increase if clinical efficacy is not achieved [66]