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Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines 31 for each of our systematic reviews, we identified studies reporting relative risk (RR) of incidence or mortality from each of the 36 selected outcomes for smokers compared with nonsmokers

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Symptoms of exposure include severe skin burns and blisters, eye irritation and blindness, respiratory tract damage, and in severe cases, death from respiratory failure