Notably, while the 2D model primarily exhibited oxidative stress-associated signatures (SBS3, SBS5 and SBS18), the organoid system showed a shift toward the smoking-related SBS4 signature
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It has been noted that at 20 mg orally, the substance causes increased heart rate, anorexia, urination, and some heat stroke for about twelve hours. In various discussion forums, doses around 100-250 mg are described